Net Terms Serial Serial means one event at a time. It is usually contrasted with parallel, which means more than one event at a time. In the context of computer hardware and data transmission, serial connection, operation and media usually indicate a simpler, slower operation. Conventional computers and their programs operate in a serial manner, with the computer reading a program and performing its instructions one after the other. For instance, because your mouse and keyboard are devices that send (but do not receive) information, they only require a serial interface and line.